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Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
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336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
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299 KEGG pathways;
876 Reactome pathways;
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last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

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DEPOD - Substrate Search Result

Protein substrate


Entry_name Gene_namesUniProtIDDescription
JAK2JAK2JAK2_HUMANTyrosine-protein kinase JAK2;2.7.10.2;Janus kinase 2;JAK-2;
ABL1ABL1, ABL, JTK7ABL1_HUMANTyrosine-protein kinase ABL1;2.7.10.2;Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Proto-oncogene c-Abl;p150;
EGFREGFR, ERBB, ERBB1, HER1EGFR_HUMANEpidermal growth factor receptor;2.7.10.1;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;
ERBB2ERBB2, HER2, MLN19, NEU, NGLERBB2_HUMANReceptor tyrosine-protein kinase erbB-2;2.7.10.1;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD340;
NTRK1NTRK1, MTC, TRK NTRK1_HUMANHigh affinity nerve growth factor receptor;2.7.10.1;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;Trk-A;gp140trk;p140-TrkA;
INSRINSRINSR_HUMANInsulin receptor;IR;2.7.10.1;CD220;Insulin receptor subunit alpha;Insulin receptor subunit beta;
LCKLCKLCK_HUMANTyrosine-protein kinase Lck;2.7.10.2;Leukocyte C-terminal Src kinase;LSK;Lymphocyte cell-specific protein-tyrosine kinase;Protein YT16;Proto-oncogene Lck;T cell-specific protein-tyrosine kinase;p56-LCK;
FYNFYNFYN_HUMANTyrosine-protein kinase Fyn;2.7.10.2;Proto-oncogene Syn;Proto-oncogene c-Fyn;Src-like kinase;SLK;p59-Fyn;
YES1YES1, YESYES_HUMANTyrosine-protein kinase Yes;2.7.10.2;Proto-oncogene c-Yes;p61-Yes;
LYNLYN, JTK8LYN_HUMANTyrosine-protein kinase Lyn;2.7.10.2;Lck/Yes-related novel protein tyrosine kinase;V-yes-1 Yamaguchi sarcoma viral related oncogene homolog;p53Lyn;p56Lyn;
RETRET , CDHF12, CDHR16, PTC, RET51RET_HUMANProto-oncogene tyrosine-protein kinase receptor Ret;2.7.10.1;Cadherin family member 12;Proto-oncogene c-Ret;Soluble RET kinase fragment;Extracellular cell-membrane anchored RET cadherin 120 kDa fragment;
IGF1RIGF1RIGF1R_HUMANInsulin-like growth factor 1 receptor;2.7.10.1;Insulin-like growth factor I receptor;IGF-I receptor;CD221;Insulin-like growth factor 1 receptor alpha chain;Insulin-like growth factor 1 receptor beta chain;
METMETMET_HUMANHepatocyte growth factor receptor;HGF receptor;2.7.10.1;HGF/SF receptor;Proto-oncogene c-Met;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met;
ROS1ROS1, MCF3, ROSROS1_HUMANProto-oncogene tyrosine-protein kinase ROS;2.7.10.1;Proto-oncogene c-Ros;Proto-oncogene c-Ros-1;Receptor tyrosine kinase c-ros oncogene 1;c-Ros receptor tyrosine kinase;
PDGFRBPDGFRB, PDGFR, PDGFR1PGFRB_HUMANPlatelet-derived growth factor receptor beta;PDGF-R-beta;PDGFR-beta;2.7.10.1;Beta platelet-derived growth factor receptor;Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-derived growth factor receptor 1;PDGFR-1;CD140b;
KITKIT, SCFRKIT_HUMANMast/stem cell growth factor receptor Kit;SCFR;2.7.10.1;Piebald trait protein;PBT;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;p145 c-kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;CD117;
SRCSRC, SRC1SRC_HUMANProto-oncogene tyrosine-protein kinase Src;2.7.10.2;Proto-oncogene c-Src;pp60c-src;p60-Src;
FGFR2FGFR2, BEK, KGFR, KSAMFGFR2_HUMANFibroblast growth factor receptor 2;FGFR-2;2.7.10.1;K-sam;KGFR;Keratinocyte growth factor receptor;CD332;
JAK1JAK1, JAK1A, JAK1BJAK1_HUMANTyrosine-protein kinase JAK1;2.7.10.2;Janus kinase 1;JAK-1;
EPHA3EPHA3, ETK, ETK1, HEK, TYRO4EPHA3_HUMANEphrin type-A receptor 3;2.7.10.1;EPH-like kinase 4;EK4;hEK4;HEK;Human embryo kinase;Tyrosine-protein kinase TYRO4;Tyrosine-protein kinase receptor ETK1;Eph-like tyrosine kinase 1;
EPHB2EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5EPHB2_HUMANEphrin type-B receptor 2;2.7.10.1;Developmentally-regulated Eph-related tyrosine kinase;ELK-related tyrosine kinase;EPH tyrosine kinase 3;EPH-like kinase 5;EK5;hEK5;Renal carcinoma antigen NY-REN-47;Tyrosine-protein kinase TYRO5;Tyrosine-protein kinase receptor EPH-3;
TYK2TYK2TYK2_HUMANNon-receptor tyrosine-protein kinase TYK2;2.7.10.2;
KDRKDR, FLK1, VEGFR2VGFR2_HUMANVascular endothelial growth factor receptor 2;VEGFR-2;2.7.10.1;Fetal liver kinase 1;FLK-1;Kinase insert domain receptor;KDR;Protein-tyrosine kinase receptor flk-1;CD309;
ZAP70ZAP70, SRKZAP70_HUMANTyrosine-protein kinase ZAP-70;2.7.10.2;70 kDa zeta-chain associated protein;Syk-related tyrosine kinase;
SYKSYKKSYK_HUMANTyrosine-protein kinase SYK;2.7.10.2;Spleen tyrosine kinase;p72-Syk;
JAK3JAK3JAK3_HUMANTyrosine-protein kinase JAK3;2.7.10.2;Janus kinase 3;JAK-3;Leukocyte janus kinase;L-JAK;
EPHA4EPHA4, HEK8, SEK, TYRO1EPHA4_HUMANEphrin type-A receptor 4;2.7.10.1;EPH-like kinase 8;EK8;hEK8;Tyrosine-protein kinase TYRO1;Tyrosine-protein kinase receptor SEK;
TEKTEK, TIE2, VMCM, VMCM1TIE2_HUMANAngiopoietin-1 receptor;2.7.10.1;Endothelial tyrosine kinase;Tunica interna endothelial cell kinase;Tyrosine kinase with Ig and EGF homology domains-2;Tyrosine-protein kinase receptor TEK;Tyrosine-protein kinase receptor TIE-2;hTIE2;p140 TEK;CD202b;
PTK2PTK2, FAK, FAK1FAK1_HUMANFocal adhesion kinase 1;FADK 1;2.7.10.2;Focal adhesion kinase-related nonkinase;FRNK;Protein phosphatase 1 regulatory subunit 71;PPP1R71;Protein-tyrosine kinase 2;p125FAK;pp125FAK;
PTK2BPTK2B, FAK2, PYK2, RAFTKFAK2_HUMANProtein-tyrosine kinase 2-beta;2.7.10.2;Calcium-dependent tyrosine kinase;CADTK;Calcium-regulated non-receptor proline-rich tyrosine kinase;Cell adhesion kinase beta;CAK-beta;CAKB;Focal adhesion kinase 2;FADK 2;Proline-rich tyrosine kinase 2;Related adhesion focal tyrosine kinase;RAFTK;
ERBB4ERBB4, HER4ERBB4_HUMANReceptor tyrosine-protein kinase erbB-4;2.7.10.1;Proto-oncogene-like protein c-ErbB-4;Tyrosine kinase-type cell surface receptor HER4;p180erbB4;ERBB4 intracellular domain;4ICD;E4ICD;s80HER4;
NTRK3NTRK3, TRKCNTRK3_HUMANNT-3 growth factor receptor;2.7.10.1;GP145-TrkC;Trk-C;Neurotrophic tyrosine kinase receptor type 3;TrkC tyrosine kinase;
NTRK2NTRK2, TRKBNTRK2_HUMANBDNF/NT-3 growth factors receptor;2.7.10.1;GP145-TrkB;Trk-B;Neurotrophic tyrosine kinase receptor type 2;TrkB tyrosine kinase;Tropomyosin-related kinase B;
ALKALKALK_HUMANALK tyrosine kinase receptor;2.7.10.1;Anaplastic lymphoma kinase;CD246;
CSKCSK, CSK_HUMANTyrosine-protein kinase CSK;2.7.10.2 {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:7683130, ECO:0000269|PubMed:9281320};C-Src kinase;Protein-tyrosine kinase CYL;
PTK6PTK6, BRK, PTK6_HUMANProtein-tyrosine kinase 6;2.7.10.2 {ECO:0000269|PubMed:12121988, ECO:0000269|PubMed:27480927, ECO:0000269|PubMed:27993680};Breast tumor kinase;Tyrosine-protein kinase BRK;

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